Insulin resistance and/or compensatory hyperinsulinemia have a central role in the pathogenesis of PCOS
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Lighter skin tone: This usually prevents further distribution of the darker pigment, thus having a radiant lighter skin tone
In this conceptual model, chemotherapy (e.g., cisplatin) initially induces an acute ROS surge, triggering immediate DNA damage responses such as ATR-Chk1 signaling to stall the cell cycle and prevent apoptosis
Llata E, Cuffe KM, Picchetti V, Braxton JR, Torrone EA